Espiradenoma écrino en muslo de mujer: reporte de un caso

Introducción: El espiradenoma ecrino es un tumor anexial benigno raro que surge de las glándulas sudoríparas écrinas. Comúnmente se presenta como un nódulo de crecimiento lento en la parte superior del tronco y la región de la cabeza y el cuello, principalmente en el rango de edad de 15 a 35 años, sin predominio de género. Por lo general, se presentan como pequeños nódulos solitarios que pueden crecer varios centímetros, a menudo muy dolorosos. El diagnóstico de esta entidad es de suma importancia ya que puede albergar un componente maligno con desenlaces catastróficos, ya que pueden pasar desapercibidos por su gran parecido con lesiones benignas. Caso Clínico: Aquí presentamos el caso de una mujer 41 años que presentó una lesión cutánea de crecimiento similar a un papiloma en la cara externa de tercio superior del muslo, con el diagnóstico de espiradenoma écrino posterior a la extirpación.

Introduction: Eccrine spiradenoma is a rare, benign adnexal tumor arising from the eccrine sweat glands. It commonly presents as a slow-growing nodule on the upper trunk, and head and neck region, mostly in the age bracket of 15 - 35 years, with no gender preference. Typically, they present as small solitary nodules that can grow to several centimeters, often they are strikingly painful. The diagnosis of this entity is extremely important as it can harbour a malignant component with catastrophic outcomes wich may be missed due to its strong resemblance to benign lesions. Case Report: We present the case of a 41-year-old woman who presented with a papilloma-like growth on the upper lateral aspect of the thigh which was diagnosed as eccrine spiradenoma upon excision.

ECCRINE SPIRADENOMA : CASE REPORT WITH AN UNUSUAL CLININAL PRESENTATION

Eccrine spiradenoma is one of the rare, benign dermal neoplasm showing eccrine sweat gland differentiation. The literature search accounts for less than 100 reported cases of eccrine spiradenoma. Clinically, the lesion presents as solitary, intradermal, circumscribed, round or oval, firm, painful or tender nodule measuring from 0.3 - 5 cm in diameter. Rarely if ES, presents as multiple lesions, in combination with other types of adnexal tumors such as cylindromas & trichoepitheliomas, it can be considered as a part of the Brooke-Spiegler syndrome. Majority of these tumours appear on the head/face & upper trunk region of the body. Spiradenomas arise in early adulthood in most instances with few reports also of congenital cases and no sex predilection seen. The definitive diagnosis is made by excisional biopsy of the tumour. Complete tumor excision with clear surgical margins is considered the primary treatment for these cases. Here, we present a rare case report of a 58 years old male presenting with a soft, cystic lesion in the left lumbar region of the abdomen for past 2 years duration. Surgical excision of the tumour was done with clear margins and the specimen was sent for histopathological examination. Due to the overlapping histomorphological features, this tumour is often confused with cylindromas and trichoepitheliomas along with other vascular tumours. Eccrine Spiradenoma, although a benign tumour, but malignant transformation has been described especially in long-standing cases or multiple lesions. So, early diagnosis is very important to prevent recurrence and to identify any onset of malignant transformation

Study on ultrasonic characteristics of eccrine spiradenomas and diagnostic efficacy / 中华超声影像学杂志

Objective:To investigate the ultrasonic characteristics of eccrine spiradenoma (ES) and to analyze the diagnostic value.Methods:Nineteen ES patients with 24 lesions confirmed by pathology in 3 grade-A tertiary hospitals from October 2011 to October 2021 were enrolled as study group, and in the same time, 46 patients with 46 masses in the skin and muscular tissues with clinical features of automatic pain and/or tenderness were selected as control group. The ultrasonographic characteristics of the two groups were analyzed retrospectively, including anatomical location, shape, boundary, internal echogenicity, echogenic distribution, calcification, posterior acoustic effect, and vascularity. The ultrasonographic characteristics of the two groups were compared, and the risk sonographic characteristics of ES were obtained by multivariate logistic regression analysis. The sensitivity and specificity of ultrasound characteristics for the diagnosis of ES were calculated.Results:The ultrasonic characteristics of the two groups had significant differences in lobulated shape, boundary, internal echogenicity and posterior acoustic effect (χ 2=32.65, 15.65, 5.77, 13.63; all P<0.01). Multivariate logistic regression analysis showed that lobulated shape and posterior acoustic enhancement were the risk ultrasonic characteristics of ES. The sensitivity and specificity of lobulated shape and posterior acoustic enhancement characteristics in the diagnosis of ES were 79.17%, 89.13%, 95.83% and 47.83%, respectively; and the sensitivity and specificity of the combination of lobulated shape and posterior acoustic enhancement characteristics in the diagnosis of ES were 79.17% and 97.83%, respectively. Conclusions:The lobulated shape and posterior acoustic enhancement characteristics are important for the identification of ES, which have higher diagnostic efficacy for ES.

Eccrine Spiradenoma

Introduction: Eccrine spiradenoma is extremely rareadnexal tumor of the sweat gland, mainly affecting middleaged persons with equal incidence in males and females. Itis frequently a benign tumor characterized as solitary, painfuldeep - seated dermal nodule with most common sites being theupper thorax and face.Case report: A 35 year old male presented with multiple,painful swellings over scalp,face,anterior chest and backsince 6 months with loss of weight and appetite for 2 months.On examination, patient had a single cervical lymph node ofsize 1*1cm in the right posterior triangle of neck. Multipletender subcutaneous, hard, nonmobile swellings present overseveral areas with largest(2*1cm) over anterior chest wall.Histopathologically diagnosed as Eccrine spiradenoma whichrevealed clusters and sheets of cells having mild pleomorphicround to ovoid bland nuclei with indistinct cytoplasmicborders, occasional duct or follicular appearance and emptylooking lumina with no necrosis or mitotic activity.Conclusion: Eccrine spiradenoma, a rare benign adnexaltumor confirmed by histopathological examination.Differential diagnosis include, Neuroma, Dermatofibroma,Glomus tumor, Angiolipoma, Cylindromas and leiomyomas.Diagnosis confirmation by histopathological examination iscrucial because of its potential for malignant transformation.Its prognosis is poor as it has multiple recurrences.Histopathological examination is gold standard for thediagnosis.

A Case of Eccrine Spiradenoma of the Eyelid

PURPOSE: To report a case of eccrine spiradenoma that presented as an eyelid nodule. CASE SUMMARY: A 61-year-old female presented with a mass in the right upper lid margin; the onset time was unknown. An ophthalmic examination revealed no abnormalities except the eyelid nodule. The nodule was 3 mm in size with a firm, smooth surface and light pinkish color, and was located near the lid margin. Excision and biopsy of the nodule was performed. The pathological findings of the specimen obtained showed islands of 2 types of lobular cells. Larger, paler cells were grouped around the central area, darker and smaller cells on the periphery. These findings were compatible with eccrine spiradenoma. CONCLUSIONS: Eccrine spiradenoma should be considered a differential diagnosis of a solitary eyelid tumor.

Multiple Segmental Eccrine Spiradenoma with a Zosteriform Pattern: A Case Report and Literature Review

Eccrine spiradenoma usually occurs as solitary tender nodules. However, it rarely occurs as multifocal localized tumors or has zosteriform distribution. We report the case of a 32-year-old woman with a 20-year history of itchy lesions on the left side of the back and forearm with a zosteriform distribution. Before disease onset, almost no patients have inducing factors, but our patient received an injection beforehand; however, whether this was coincidental or causative remains unknown. The lesions became very itchy after perspiration or eating spicy food, which has never been reported. A literature search revealed 22 cases of multiple segmental eccrine spiradenoma; we summarized the clinical characteristic in order to aid diagnosis and treatment selection.

A Case of Multiple Eccrine Spiradenoma in an Annular Distribution / 대한피부과학회지

Eccrine spiradenoma is a rare, benign, slow-growing adnexal neoplasm. It has been historically designated as an eccrine tumor, but is now considered an apocrine tumor. It typically presents as a single, tender, pink-to-blue, well-defined intradermal or deeply subcutaneous nodule on the head or trunk. In rare cases, multiple tumors are present and can be arranged in various patterns including zosteriform and/or linear distributions. A 40-year-old female patient presented with a 7-year history of multiple, small, tender nodules distributed in an annular pattern on her left shoulder. The diagnosis of eccrine spiradenoma was made by clinical and histopathological findings, and the larger nodules were surgically removed. We herein present an unusual case of multiple eccrine spiradenoma in an annular distribution.

Giant Vascular Eccrine Spiradenoma

Giant vascular eccrine spiradenomas (GVESs) are a rare variant of the eccrine spiradenoma that develops from the sweat gland. It is different from the eccrine spiradenoma in its larger size and greater degree of vascularity. Bleeding and/or ulceration are common clinical features of this tumor, and are the reason why it is often clinically confused with a vascular or malignant tumor. Here, a rare case of GVES without bleeding or ulceration is reported.

Eccrine Spiradenoma Arising in the Breast Misdiagnosed as an Epidermal Inclusion Cyst

Eccrine spiradenomas are rare, benign, cutaneous tumors that originate in the sweat glands. Eccrine spiradenomas in the breast are very rare and only a few cases have been reported. We report here on the case of a 47-year-old woman with superficial masses in the breast and these masses had gradually increased in size during follow-up. They were confirmed to be an eccrine spiradenoma on pathologic examination. There have been a few reports about the radiologic findings of eccrine spiradenomas of the breast. This is the first case of an eccrine spiradenoma in the breast that was characterized by multiple imaging modalities, including mammography, ultrasonography and MRI. The lesion in our patient was first diagnosed as an epidermal inclusion cyst based on the imaging findings and the mass's superficial location. Although the mammographic and ultrasonographic imaging findings of eccrine spiradenomas and epidermal inclusion cysts are similar, the MRI findings are different between epidermal inclusion cysts and eccrine spiradenomas. Eccrine spiradenomas should be considered in the differential diagnosis of cutaneous and subcutaneous lesions of the breast.

A Case of Cystic Eccrine Spiradenoma on the Left Leg / 대한피부과학회지

Eccrine spiradenoma is a benign tumor that is differentiated into the direction of an eccrine gland. It is usually presents as a solitary, slowly-growing, intradermal or deeply subcutaneous nodule on the head and trunk. We report on a case of 32-year-old woman with a solitary, solid mass on the left leg that she'd had for 6 months. The mass was a 2.5x2x0.5 cm sized, round shaped, well demarcated solitary skin-colored nodule. The mass in our case was a relatively large and painful eccrine spiradenoma, and the mass showed cystic formation. The cyst was surrounded by cords of tumor cells. Hyaline materials were seen focally. There were two types of cells. Large pale nuclei existed adjacent to the cyst. Small dark nuclei existed at the periphery. To clarify the histogenesis of this tumor, immunohistochemical staining using various antibodies was also performed. We herein report on an unusual case of a large cystic eccrine spiradenoma.

A Case of Eccrine Spiradenoma in a Patient with Neurofibromatosis

Neurofibromatosis is a systemic hereditary disorder with varied manifestations in bone, soft tissue, the nervous system and skin. Cutaneous manifestations of neurofibromatosis are characterized by cafe-au-lait macules, multiple neurofibromas, Lisch nodules and intertriginous freckling. Some benign or malignant tumors such as juvenile xanthogranuloma, pheochromocytoma, and malignant melanoma can accompany neurofibromatosis. But, in the English literature, no case of eccrine spiradenoma associated with neurofibromatosis has been reported. Eccrine spiradenoma is a benign uncommon neoplasm of skin adnexa. It presents as a painful, slow-growing and solitary nodule on the head or upper trunk. Here, we report a rare case of eccrine spiradenoma in a patient with neurofibromatosis.

Eccrine spiradenoma with chondroid syringoma in Blaschkoid distribution.

Eccrine spiradenoma (ES) very rarely presents in a linear or zosteriform distribution. It may be associated with foci of various other appendageal tumors. We report a 14-year-old boy who presented to us with multiple nodules in a linear distribution in the posterior aspect of the right lower limb since 2 years of age. The lesions became significantly painful for the past 2 years. Histopathology revealed dermal lobules of ES with smaller foci of chondroid syringoma.

A Case of Eccrine Spiradenoma in a Neurofibromatosis Type-1 Patient / 대한피부과학회지

Eccrine spiradenoma is a rare benign tumor which is differentiated into the direction of eccrine gland. Neurofibromatosis type-1 is an autosomal dominantly inherited disorder that is characterized by neurofibroma, cafe au lait spots and axillary freckles of the skin. We report a case of a 42-year-old man with a painful, solid nodule on his right arm for 4~5 months. He was diagnosed with neurofibromatosis type-1 in childhood. He has several cafe au lait spots and diffuse freckles on whole body. On microscopy, the tumor was sharply demarcated with encapsulated lobules in the dermis. The lobules consisted of two undifferentiated epithelial cells. There was hyperpigmentation of the basal cell layer in the epidermis without increase in the number of melanocyte. We herein report an unusual case of eccrine spiradenoma in neurofibromatosis type-1 patient.

Espiroadenoma ecrino de presentación inusual en párpado / Eccrine spiradenoma of inusual presentation on the eyelid

Reportamos el caso de un espiroadenoma ecrino en una paciente de 90 años de edad, que empezó un año antes de la consulta con una lesión en el párpado. Se trata de un tumor benigno de la glándulas sudoríparas que es raro en el párpado. Al principio pensamos en otro tumor, como el carcinoma sebáceo, por su rápido crecimiento. La posibilidad de un tumor de glándulas sudoríparas debiera considerarse en el diagnóstico de tumores palpebrales.

We report a case of an eccrine spiradenoma in a 90 years old woman, who began a year before with the lesion on the eyelid. It is a begin sweat gland tumor, that is rare on the eyelid. At the beginning we thougth in an other tumor, like sebaceous carcinoma for its quick growth. The possibility of sweat gland tumor should be kept in mind in the diagnosis of eyelid tumours.

A Case of Multiple Eccrine Spiradenoma with Zosteriform Distribution / 대한피부과학회지

Eccrine spiradenoma is a benign tumor which probably originats in the coil of the eccrine sweat gland. It usually presents as a solitary, slowly-growing, sometimes painful, reddish-brown, and intradermal or deeply subcutaneous nodule on the head and trunk. More than 97% of eccrine spiradenoma appear as solitary lesions. Occasionally, it may appear as multiple lesions, however they are rarely arranged in a linear or zosteriform distribution. A search of literature revealed only 17 internationally reported cases of linear or zosteriform eccrine spiradenomas, including 4 Korean cases. We herein present an unusual case of eccrine spiradenoma, showing multiple, large nodules with zosteriform distribution.

A Case of Giant Vascular Eccrine Spiradenoma / 대한피부과학회지

Giant vascular eccrine spiradenoma is a rare benign tumor of the sweat gland, which differs from common eccrine spiradenoma in both its larger size and marked vascularity. It is emphasized that this rare type of spiradenoma is commonly misdiagnosed as an angiomatous lesion or a malignant tumor due to its hemorrhagic and ulcerative features. We report a rare case of giant vascular ecrine spiradenoma that was mistaken as a malignant tumor due to hemorrhaging and ulceration.

Giant Vascular Eccrine Spiradenoma: Report of a Case with Immunohistochemical Study

We report a rare case of giant vascular eccrine spiradenoma (GVES) which developed in 56-yr-old Korean woman. It is a rare variant of eccrine spiradenoma (ES), which might be mistaken for angiomatous lesions in view of its florid vascularity and hemorrhagic features. Histogenesis of GVES is not clearly elucidated although it is known that ES presumably originates in the eccrine glands. To clarify the histogenesis of GVES, immunohistochemical stainings using various monoclonal antibodies were also performed. The tumor was composed of three types of cells, namely pale epithelial cells, small basal cells, and myoepithelial cells. Therefore, we conclude that GVES originated from eccrine gland and mainly differentiates toward secretory portion of secretory coil.

A Case of Multiple Eccrine Spiradenomas with Zosteriform Distribution / 대한피부과학회지

Eccrine spiradenoma is clinically characterized by a slowly growing, deep-seated nodule occurring most frequently on the ventral surface of the body. It is solitary in 95% of cases. Rarely, multiple lesions may be present and may occur in a linear or zosteriform pattern. Until now only two cases of eccrine spiradenoma in zosteriform pattern have been reported in Korean literatures. A 19-year-old male presented with multiple, gray, macular lesions in a zosteriform distribution along his left subscapular area. These 10-years-old lesions gave him occasional paroxysmal pain. Two years later, the lesions became palpable in the subcutis and were diagnosed as eccrine spiradenoma by an excision biopsy. During the 4 years thereafter, the remaining lesions grew slightly and became symptomatic, which resulted in a second surgical removal. We report a rare case of multiple eccrine spiradenomas with zosteriform distribution with observation of 6 years course.

A Case of Multiple Eccrine Spiradenoma associated with Multiple Trichoepithelioma / 대한피부과학회지

Eccrine spiradenoma is a benign adnexal tumor which is differentiated into the direction of eccrine gland. Occasionally, eccrine spiradenoma is associated with other skin tumors, especially cylindroma or trichoepithelioma. A 55-year-old woman with multiple trichoepithelioma on the face presented with paroxysmally painful three papules on the face and the right arm for 5 months. On low magnification, the tumor was a sharply demarcated lobule surrounded by a fibrous capsule in the dermis. On higher magnification, the lobule is composed of basophilic cells arranged in characteristic small rosettes, two cell types of which are large central cells of pale nuclei and small peripheral cells of dark nuclei. We, herein, report an unusual case of multiple eccrine spiradenoma associated with multiple trichoepithelioma.

A Case of Eccrine Spiradenoma on the Scrotum / 대한피부과학회지

Eccrine spiradenoma is a benign, usually a solitary intradermal tumor with a characteristic clinical and pathological picture. Even though eccrine spiradenoma shows no characteristic distribution, it usually occurs on the ventral surface of the body, especially over the upper half including head and neck. Here we present a case of eccrine spiradenoma which occurred at an unusual site, the scrotum. The scrotum in our case is a relatively rare site for eccrine spiradenoma albeit the fact that histogenesis of tumor is uncertain.